The Definitive Guide to ceesdekker

The Definitive Guide to ceesdekker

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Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our exploration passions contain:

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The following articles or blog posts are merged in Scholar. Their mixed citations are counted only for the primary short article.

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and metallic clusters

We build stage-of-treatment diagnostics take a look at of neglected tropical ailments within just source-limited configurations, determined by Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.

SMC complexes can pass Actual physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental position of spatial confinement for the molecular and mobile degree. Our tasks contain the following:

Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in purple, along with a 3D rendering with the motion with the DNA rod is displayed.

The rotors harness Electrical power from the nanoscale water and ion stream that is certainly generated by a static chemical or electrochemical opportunity gradient in the nanopore, which might be proven through a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological disorders, suggesting solutions to constructing Electrical power-transducing motors at nanoscale interfaces.

There was a person problem although — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these kinds of good conductors, which was somewhat disappointing. We So broadened our perspective to test to uncover extra promising molecules.

An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes

‘That worries the artificial cell, as Component of the Dutch BaSyC initiative. Craig Venter looked best-down in Those people days and determined about 5 hundred genes which are minimally expected for a working mobile. We wish to look bottom-up: how can we shift from a handful of molecules to a complete biological technique?

Electrical https://www.ceesdekker.net transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes

The biophysicist from Delft – who has become The most cited scientists in the Netherlands for years – usually takes his accountability to lead towards the rationalization and popularisation of his get the job done with the border of physics and biology incredibly seriously and consistently seems within the media; Otherwise to mention his perform, then about the connection involving science and his Christian faith.